Granulocyte-macrophage colony-stimulating factor and azidothymidine in patients with acquired immunodeficiency syndrome.
نویسندگان
چکیده
To the Editor: neutropenic acquired immunodeficiency syndrome (AIDS) patients did not increase HIV as determined by cell culture. Mitsuyasu et a13 reported on 15 HIV-infected patients administered GM-CSF for up to 6 months without a consistent change in HIV expression, and we have recently completed a study of GM-CSF with daily AZT in 19 patients with no consistent increase in p24.' In vitro data using HIV-infected mononuclear phagocytes suggests that GM-CSF may stimulate virus production, although this may be dependent on the viral strain and specific cell lines used? In contrast, data from in vitro studies using the combination of AZT and GM-CSF show that GM-CSF enhances the anti-HIV effect of AZT.6,' In their recent report of granulocyte macrophage colonystimulating factor (GM-CSF) used in an alternating regimen with azidothymidine (AZT) in human immunodeficiency virus (HIV) patients with leukopenia, Pluda et al' showed that six patients with detectable p24 at baseline had significant increases during the period of GM-CSF administration. Although most patients had subsequent decreases in p24 when AZT was later added, this data may raise a safety concern about giving GM-CSF to HIV patients. The clinical experience suggests that this concern may not be warranted. In a study by Groopman et al: GM-CSF given alone in
منابع مشابه
Comparison of T7- and Lac-Based Systems for the Periplasmic Expression of Human Granulocyte Macrophage Colony Stimulating Factor in Escherichia coli
متن کامل
Expression and Secretion of Human Granulocyte Macrophage-Colony Stimulating Factor Using Escherichia coli Enterotoxin I Signal Sequence
With the aim of the secretion of human granulocyte macrophage-colony stimulating factor (hGM-CSF) in Escherichia coli, hGM-CSF cDNA was fused in-frame next to the signal sequence of ST toxin (ST-I) of exteroxigenic E. coli, containing 53 or 19 amino acids of signal peptide. The fused STsig::hGM-CSF coding fragments were inserted into a T7-based expression plasmid. The recombinant plasmids were ...
متن کامل1997 USPHS/IDSA Report on the Prevention of Opportunistic Infections in Patients Infected With Human Immunodeficiency Virus
ABBREVIATIONS. USPHS, US Public Health Service; IDSA, Infectious Diseases Society of America; HIV, human immunodeficiency virus; PCP, Pneumocystis carinii pneumonia; TE, toxoplasmic encephalitis; MAC, Mycobacterium avium complex; AIDS, acquired immunodeficiency syndrome; TB, tuberculosis; TMP/ SMZ, trimethoprim/sulfamethoxazole; BI, bacterial infections; TST, tuberculin skin test; PPD, purified...
متن کامل1997 USPHS/IDSA Report on the Prevention of Opportunistic Infections in Patients Infected With Human Immunodeficiency Virus
ABBREVIATIONS. USPHS, US Public Health Service; IDSA, Infectious Diseases Society of America; HIV, human immunodeficiency virus; PCP, Pneumocystis carinii pneumonia; TE, toxoplasmic encephalitis; MAC, Mycobacterium avium complex; AIDS, acquired immunodeficiency syndrome; TB, tuberculosis; TMP/ SMZ, trimethoprim/sulfamethoxazole; BI, bacterial infections; TST, tuberculin skin test; PPD, purified...
متن کاملSafety of GM-CSF in patients with AIDS: a review of the literature.
We performed a literature search for all clinical studies reporting outcomes in patients with the acquired immunodeficiency syndrome (AIDS) receiving granulocyte-macrophage colony-stimulating factor (GM-CSF) for any indication. Safety outcomes included human immunodeficiency virus replication, immune status, and frequency of opportunistic infections and neoplasms. Data were synthesized qualitat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Blood
دوره 77 9 شماره
صفحات -
تاریخ انتشار 1991